The inverter is an Eco-Worthy 10KW unit which, like many others you can buy, is just a re-badged SRNE inverter.

It's got two MPPT channels, and the PV input voltage range is 100-500v DC.

I'm planning the layout and wondering if I can have my main string of 12 south-facing panels in series going to MPPT1 at 288 volts and a secondary string of 8 panels going into MPP2 at 192 volts. Trying to make the most of my limited west and south-facing roof real estate.

I can definitely ask the manufacturer support, but figured this was a basic enough question I'd ask here first and possibly get an answer faster.

Yes, that's the main purpose of having 2 inputs.

That's what I assumed but wanted to be 100% sure before i committed to two different sized strings. Thanks!

They have to. Imagine you attach the same amount of panels to each channel. In theory you should get the same voltage on both sides. Now imagine a shadow falling on one set of panels. Which means instant voltage drop on that side. You surely agree that the inverter should be able to deal with that kind of situation?