Why has there not been a ‘Star Trek’ series or series of movie that involves people with super intelligence & skills like that, but the challenges go along with it? Half joking, but ‘Big Bang Theory’s* character Shelton would work & be funny. Shelton fanboy did not pay me to say that or have something on me to force me to say that. Heck the other ‘Big Bang Theory’s character characters would also work & be funny.
But a lot more serious, there are some challenges that give people traits that makes them the perfect crew members.

*- Funnies comedy of all time, The GOAT!

FYI, Sheldon's name's spelled with a d, not a t.

I think one main reason we've not seen such a series, is because of the negative backlash boy wonder Wesley Crusher got.

If done well, I'd love to see a flawed-genius trek.

[PS, Sheldon's my fave TBBT (&YS) character, and the DS9 episodes with those genetically engineered characters are my fave, and they're my fave side characters of all star trek (up there with the traveller, tuvix, & kai opaca). IMO exceptional brilliance aught not be shied away from.]