I was born into & will die with Learning Challenges (in- language processing & short & long term memories), have earned degree in SLD, many certifications, including VE & ESE, from the most respected higher educational school in Fl., whatever that is worth, & facilitated learning in Elementary schools’-high schools’-adult education school’s ESE & Etc. classrooms. So I understand that challenges can be extremely hard identify-prove & everywhere, I think everyone has a challenge, to some degree.

Yet I cannot understand the challenges that genetic engineered friends of Dr. Bashir character Lauren (played by Hillary Shepard) & Patrick (played by Michael Keenan).
The only thing that comes close to challenges I see in-
Lauren having is higher attraction drive to men, than the average person
&
Patrick having is he is easily manipulated-to easy to go along with others, especially by Jack.

Lauren thing seems like UPN censored away the writers from going to a real challenge & forced them to her being just higher attraction drive to men, than the average person, which is not a challenge.
&
Patrick thing is not even close to being a challenge at all, maybe, lack confidence or whatever, but not a challenge, while Lauren is also not a challenge, I can understand that if the writers were not censored away from her being sex addiction, then that would been a challenge.

Their biggest challenge, their biggest hurdle, their biggest impediment to being free to contributing to society, is not in them, but in the rules on them, based on the well founded fears of creating a race to the bottom with a million Khans seeking to take over and rule over everybody else (like happened before), if genetic engineering were considered acceptable. This is covered in the side conversations had in the episodes featuring them.

Not completely distinct from neurodiversity challenges. The biggest hurdle being from society not built to accommodate us.