Link: https://www.scientificamerican.com/article/the-gut-microbiome-may-influence-brain-aging-mouse-study-suggests/

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Inflammation (Inflammaging), and Vagus Nerve

“It’s definitely not impossible to imagine a future where people stimulate their vagus nerve to counteract cognitive decline,” Thaiss says. “But we would need larger studies and clinical trials in order to figure this out.”

For those interested you may wish to look into the topics of taVNS (transcutaneous auricular Vagus Nerve Stimulation), and using any/all means necessary to broaden your microbiome, e.g. prebiotics + probiotic = synbiotics.

From the article:

Intestinal interoceptive dysfunction drives age-associated cognitive decline
https://www.nature.com/articles/s41586-026-10191-6

Microbiota from young mice counteracts selective age-associated behavioral deficits
https://www.nature.com/articles/s43587-021-00093-9